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Beyond Transcriptional Shutdown: Expanding the Frontier o...
2025-10-20
This thought-leadership article reframes the cancer apoptosis paradigm in light of recent discoveries that RNA Pol II inhibition triggers apoptosis independently of transcriptional loss. By integrating mechanistic insights from the latest Cell study with the strategic deployment of ABT-263 (Navitoclax), we provide translational researchers with actionable guidance for modeling, dissecting, and therapeutically targeting mitochondrial and transcription-independent cell death pathways in cancer biology.
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Trypsin in Proteolytic Enzyme Research: Mechanistic Insig...
2025-10-19
Explore the pivotal role of Trypsin, a serine protease, in protease signaling pathways, cell proliferation, and advanced studies of wound healing and neurogenic inflammation. This article delivers mechanistic depth, unique applications, and perspectives not found in existing resources.